SermorelinCompare

Follow the evidence.

Original study papers and regulatory documents behind the comparisons. Each source lists its publication date and identifier.

In this guide

Original documents

Numbered citations in a comparison link to the relevant document below. A study of one peptide or population does not automatically support a claim about another.

9 documents, in the order the figures above use them. The date on each is the one printed on the document.

  1. Esposito P, Barbero L, Caccia P, Caliceti P, D'Antonio M, Piquet G, Veronese FM. PEGylation of growth hormone-releasing hormone (GRF) analogues. Advanced Drug Delivery Reviews, volume 55, issue 10, pages 1279–1291.Document date: 2003-09-26. PMID 14499707, doi:10.1016/s0169-409x(03)00109-1.
  2. Food and Drug Administration, Department of Health and Human Services. Determination That GEREF (Sermorelin Acetate) Injection, 0.5 Milligrams Base/Vial and 1.0 Milligrams Base/Vial, and GEREF (Sermorelin Acetate) Injection, 0.05 Milligrams Base/Amp, Were Not Withdrawn From Sale for Reasons of Safety or Effectiveness. Federal Register, volume 78, number 42, pages 14095–14096, Notice.Document date: published 2013-03-04, signed 2013-02-26. 78 FR 14095, FR Doc. 2013-04827, Docket No. FDA-2012-P-1071.
  3. Dominikowski A, Rękoś Z, Olejarz M, Szczepanek-Parulska E, Domin R, Ruchała M. The emerging landscape of performance-enhancing peptides modulating GH-IGF1 axis: bridging the gap between clinical evidence and patient self-administration. Frontiers in Endocrinology, volume 17, article 1822475.Document date: 2026-06-18. PMID 42395176, PMC13322892, doi:10.3389/fendo.2026.1822475.
  4. Theratechnologies Inc., prescribing information approved by the Food and Drug Administration. EGRIFTA SV (tesamorelin) for injection, for subcutaneous use — full prescribing information. DailyMed structured product label, National Library of Medicine.Document date: label face date: Revised 03/2024; label version published 2026-07-31. SPL set id 3d783378-b02d-4f19-99dd-0fc91a042224, Initial U.S. Approval 2010.
  5. Theratechnologies Inc., prescribing information approved by the Food and Drug Administration. EGRIFTA WR (tesamorelin) for injection, for subcutaneous use — full prescribing information. DailyMed structured product label, National Library of Medicine.Document date: label face date: Revised 03/2025; label version published 2026-08-03. SPL set id 839334d3-8c1d-4c26-9036-2ab524a6ea75, Initial U.S. Approval 2010.
  6. Venkova K, Mann W, Nelson R, Greenwood-Van Meerveld B. Efficacy of ipamorelin, a novel ghrelin mimetic, in a rodent model of postoperative ileus. Journal of Pharmacology and Experimental Therapeutics, volume 329, issue 3, pages 1110–1116.Document date: 2009-06. PMID 19289567, doi:10.1124/jpet.108.149211.
  7. Gobburu JV, Agersø H, Jusko WJ, Ynddal L. Pharmacokinetic-pharmacodynamic modeling of ipamorelin, a growth hormone releasing peptide, in human volunteers. Pharmaceutical Research, volume 16, issue 9, pages 1412–1416.Document date: 1999-09. PMID 10496658, doi:10.1023/a:1018955126402.
  8. Raun K, Hansen BS, Johansen NL, Thøgersen H, Madsen K, Ankersen M, Andersen PH. Ipamorelin, the first selective growth hormone secretagogue. European Journal of Endocrinology, volume 139, issue 5, pages 552–561.Document date: 1998-11. PMID 9849822, doi:10.1530/eje.0.1390552.
  9. Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohman LA. Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults. Journal of Clinical Endocrinology and Metabolism, volume 91, issue 3, pages 799–805.Document date: 2006-03. PMID 16352683, doi:10.1210/jc.2005-1536.

Reading the evidence

Check the exact molecule, study population, intervention and outcome. Where a document reports a range, we retain both ends. Where a human measurement is not reported, we say so instead of supplying a number.

A label's date matters. Different editions may describe different products, populations or measurements. The source list identifies the document itself; an article's revision date does not mean every underlying study is new.

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